General description

A cell-permeable quinoline compound that targets the nicotinamide-binding site and acts as a reversible sirtuin 2- (SIRT2) selective inhibitor (IC₅₀ = 3.5 µM) with little activity against SIRT1/3 (IC₅₀ >50 µM). Prevents cellular α-tubulin deacetylation in HeLa cells in a dose-dependent manner and with little cytotoxic effect. Shown to rescue α-Synuclein-mediated toxicity both in primary rat embryo midbrain cultures in vitro and in a Drosophila PD model in vivo. The inactive isomer AGK7 (Cat. No. 566326) can be used as a negative control.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Outerio, T.F., et al. 2007. Science317, 516.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Preparation Note

Slight warming may be required for complete solubilization.

Warning

Toxicity: Standard Handling (A)